Why does tissue acidosis slow the onset of local anesthesia?

Why does tissue acidosis slow the onset of local anesthesia?

• A. Acidosis increases the proportion of ionized drug, reducing its ability to cross nerve membranes and delaying onset.
• B. Acidosis increases nonionized drug, speeding onset.
• C. pH changes increase blood flow to tissue, washing away drug.
• D. Acidic tissue enhances membrane permeability.

Answer: (A)